Some hematological indices and plasma biochemical parameters were determined in two Capoeta; C.trutta and C.damascina from Gheshlagh Dam Lake, Sanandaj based on seasonal changes and thier age and gender dependent.There was no gender dependent significant difference in hematological indices of both species. Comparsion of indices between the two studied species showed that neutrophil and monocyte percentages, erythrocyte count, hematocrit, hemoglobin concentration, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration were significantly higher in C.damascina however, the percentage of lymphocyte was higher in C.trutta than C.damascina. Total leukocyte count, monocyte percentage and plasma total protein of C.trutta were significantly different among 2-4 years old classes, however there was no significant difference between indices of C.damascina for the same age groups. The effect of season on blood indices of C.damascina showed that the highest total leukocyte count and plasma phosphorus concentration were attained in summer, while the highest values for monocyte percentage and hematocrit were observed during winter. Erythrocyte count and hematocrit of C. trutta were raised in winter and mean corpuscular hemoglobin was decreased in this season. The study has provided baseline haematological and some biochemical data of C.damascina and C.trutta which could be used in health monitoring and future comparative surveys of these species.